Endocrine Abstracts

Reactive oxygen species (ROS) are involved in the pathogenesis of atherosclerosis. Atrial natriuretic peptide (ANP) reduces thioredoxin in heart failure patients, whereas adrenomedullin, acting as an antioxidant, protects rat cardiomyocytes from infarction and mouse vascular smooth muscle cells from angiotensin II (AII) oxidative effect. Besides AII, aldosterone (Aldo) is also an activator of ROS. Aim of the study was the investigation of the eventual antioxidant effect of ANP...

Introduction: Aldosterone (Aldo) decreases the rate of repolarization in rabbit cardiomyocytes and significantly increases the duration of the monophasic action potential in patients with supraventricular arrhythmias, few minutes after its intravenous administration, implying for a non-genomic action. We have previously found a positive linear regression between left ventricular systole duration and plasma Aldo levels in NZW rabbits. To investigate the veracity of the above fi...